Enables signaling receptor binding activity and trans-2-enoyl-CoA reductase (NADPH) activity. Involved in phytol metabolic process. Located in peroxisome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PECR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PECR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PECR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:215,905,935–215,906,837 | 175.3 kb | Distal (>10kb) Multiome | 76 | |
| chr2:216,012,871–216,013,914 | 68.3 kb | Distal (>10kb) Multiome | 664 | |
| chr2:216,081,343–216,082,368 | 65 bp | At TSS Multiome | 872 | |
| chr2:216,083,940–216,084,292 | 2.2 kb | Proximal (<10kb) | 197 | |
| chr2:216,109,035–216,110,011 | 27.6 kb | Distal (>10kb) Multiome | 866 | |
| chr2:216,114,288–216,115,514 | 33.1 kb | Distal (>10kb) Multiome | 671 | |
| chr2:216,275,236–216,275,858 | 193.7 kb | Distal (>10kb) Multiome | 120 | |
| chr2:216,283,571–216,284,041 | 202.0 kb | Distal (>10kb) Multiome | 206 | |
| chr2:216,292,640–216,293,553 | 211.4 kb | Distal (>10kb) Multiome | 205 | |
| chr2:216,317,598–216,318,777 | 236.2 kb | Distal (>10kb) Multiome | 193 | |
| chr2:216,339,679–216,340,452 | 258.4 kb | Distal (>10kb) Multiome | 192 | |
| chr2:216,345,559–216,346,320 | 264.2 kb | Distal (>10kb) Multiome | 100 | |
| chr2:216,370,964–216,372,465 | 290.6 kb | Distal (>10kb) Multiome | 850 |
Genomic view of the PECR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.