This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and cancer metastasis. [provided by RefSeq, Mar 2014]
Transcription factors with Perturb-seq knockdown data for PEAK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PEAK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PEAK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:77,419,234–77,421,343 | 144 bp | At TSS Multiome | 941 | |
| chr15:77,496,731–77,497,500 | 77.0 kb | Distal (>10kb) Multiome | 517 | |
| chr15:77,510,024–77,510,883 | 90.3 kb | Distal (>10kb) Multiome | 121 | |
| chr15:77,525,254–77,525,853 | 105.4 kb | Distal (>10kb) Multiome | 43 | |
| chr15:77,528,312–77,529,264 | 108.7 kb | Distal (>10kb) Multiome | 100 | |
| chr15:77,543,155–77,543,857 | 123.4 kb | Distal (>10kb) Multiome | 680 | |
| chr15:77,604,253–77,604,752 | 184.4 kb | Distal (>10kb) Multiome | 145 | |
| chr15:77,623,073–77,623,871 | 203.4 kb | Distal (>10kb) Multiome | 292 | |
| chr15:77,630,922–77,631,706 | 211.2 kb | Distal (>10kb) Multiome | 92 | |
| chr15:77,632,252–77,635,007 | 214.7 kb | Distal (>10kb) Multiome | 831 |
Genomic view of the PEAK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.