The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PDXK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDXK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDXK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:43,659,125–43,659,916 | 59.5 kb | Distal (>10kb) Multiome | 989 | |
| chr21:43,718,478–43,719,766 | 7 bp | At TSS Multiome | 782 | |
| chr21:43,728,503–43,729,213 | 9.7 kb | Proximal (<10kb) Multiome | 905 | |
| chr21:43,740,577–43,741,104 | 21.8 kb | Distal (>10kb) Multiome | 198 | |
| chr21:43,775,786–43,776,893 | 57.3 kb | Distal (>10kb) Multiome | 782 | |
| chr21:43,788,879–43,790,067 | 70.3 kb | Distal (>10kb) Multiome | 930 | |
| chr21:43,864,215–43,864,709 | 145.2 kb | Distal (>10kb) Multiome | 538 | |
| chr21:43,865,135–43,865,798 | 146.4 kb | Distal (>10kb) Multiome | 333 | |
| chr21:43,883,997–43,884,476 | 165.2 kb | Distal (>10kb) Multiome | 418 | |
| chr21:43,921,393–43,922,764 | 202.8 kb | Distal (>10kb) Multiome | 622 | |
| chr21:44,011,848–44,013,192 | 293.5 kb | Distal (>10kb) Multiome | 873 |
Genomic view of the PDXK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.