This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq, Jul 2015]
Transcription factors with Perturb-seq knockdown data for PDS5B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDS5B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDS5B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:32,314,935–32,316,400 | 271.0 kb | Distal (>10kb) Multiome | 896 | |
| chr13:32,409,564–32,410,449 | 176.6 kb | Distal (>10kb) Multiome | 262 | |
| chr13:32,426,853–32,428,509 | 159.2 kb | Distal (>10kb) Multiome | 737 | |
| chr13:32,537,977–32,539,319 | 47.7 kb | Distal (>10kb) Multiome | 749 | |
| chr13:32,585,638–32,587,422 | 143 bp | At TSS Multiome | 786 | |
| chr13:32,587,527–32,587,841 | 985 bp | At TSS | 248 |
Genomic view of the PDS5B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.