PDPK1
3-phosphoinositide dependent protein kinase 1 | PDK1

Enables 3-phosphoinositide-dependent protein kinase activity; phospholipase activator activity; and phospholipase binding activity. Involved in several processes, including cell surface receptor signaling pathway; intracellular signaling cassette; and regulation of signal transduction. Acts upstream of or within intracellular signal transduction. Located in cell projection; cytosol; and plasma membrane. Implicated in prostate cancer. Biomarker of lung non-small cell carcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Developmental clusters: GC1
Biological processes 60 terms
3-phosphoinositide-dependent protein kinase activity (GO:0004676)3-phosphoinositide-dependent protein kinase activity (GO:0004676)ATP binding (GO:0005524)T cell costimulation (GO:0031295)actin cytoskeleton organization (GO:0030036)calcium-mediated signaling (GO:0019722)cell migration (GO:0016477)cell projection (GO:0042995)cellular response to epidermal growth factor stimulus (GO:0071364)cellular response to insulin stimulus (GO:0032869)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasmic vesicle (GO:0031410)cytosol (GO:0005829)cytosol (GO:0005829)epidermal growth factor receptor signaling pathway (GO:0007173)extrinsic apoptotic signaling pathway (GO:0097191)focal adhesion (GO:0005925)insulin receptor signaling pathway (GO:0008286)insulin receptor signaling pathway (GO:0008286)insulin-like growth factor receptor signaling pathway (GO:0048009)intracellular signal transduction (GO:0035556)intracellular signal transduction (GO:0035556)intracellular signaling cassette (GO:0141124)membrane (GO:0016020)negative regulation of apoptotic process (GO:0043066)negative regulation of cardiac muscle cell apoptotic process (GO:0010667)negative regulation of endothelial cell apoptotic process (GO:2000352)negative regulation of toll-like receptor signaling pathway (GO:0034122)negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512)nucleus (GO:0005634)phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0043491)phospholipase activator activity (GO:0016004)phospholipase binding (GO:0043274)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of angiogenesis (GO:0045766)positive regulation of blood vessel endothelial cell migration (GO:0043536)positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051897)positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051897)positive regulation of protein localization to plasma membrane (GO:1903078)positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)positive regulation of sprouting angiogenesis (GO:1903672)positive regulation of vascular endothelial cell proliferation (GO:1905564)postsynaptic density (GO:0014069)protein autophosphorylation (GO:0046777)protein binding (GO:0005515)protein kinase activity (GO:0004672)protein phosphorylation (GO:0006468)protein serine kinase activity (GO:0106310)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)regulation of canonical NF-kappaB signal transduction (GO:0043122)regulation of endothelial cell migration (GO:0010594)regulation of mast cell degranulation (GO:0043304)type B pancreatic cell development (GO:0003323)vascular endothelial cell response to laminar fluid shear stress (GO:0097700)
Expression (TPM)
PDPK1 — as a Regulated Gene

TFs regulating PDPK1 0 TFs

Transcription factors with Perturb-seq knockdown data for PDPK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDPK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to PDPK1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDPK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr16:2,251,044–2,252,460 286.3 kb Distal (>10kb) Multiome 996
chr16:2,267,625–2,269,111 269.7 kb Distal (>10kb) Multiome 1044
chr16:2,339,631–2,342,283 197.2 kb Distal (>10kb) Multiome 1129
chr16:2,428,282–2,429,948 108.7 kb Distal (>10kb) Multiome 827
chr16:2,459,524–2,460,612 77.9 kb Distal (>10kb) Multiome 670
chr16:2,467,565–2,468,324 70.2 kb Distal (>10kb) Multiome 450
chr16:2,470,913–2,472,223 66.7 kb Distal (>10kb) Multiome 427
chr16:2,473,455–2,476,127 62.8 kb Distal (>10kb) Multiome 719
chr16:2,501,124–2,501,877 36.5 kb Distal (>10kb) Multiome 471
chr16:2,513,006–2,514,809 24.2 kb Distal (>10kb) Multiome 818
chr16:2,520,064–2,520,618 17.6 kb Distal (>10kb) Multiome 624
chr16:2,531,456–2,533,080 5.9 kb Proximal (<10kb) Multiome 883
chr16:2,537,433–2,538,433 104 bp At TSS Multiome 498
chr16:2,603,176–2,603,939 65.4 kb Distal (>10kb) Multiome 1066
chr16:2,673,059–2,673,910 135.5 kb Distal (>10kb) Multiome 471
chr16:2,682,205–2,683,006 144.5 kb Distal (>10kb) Multiome 1003
chr16:2,720,741–2,721,896 183.3 kb Distal (>10kb) Multiome 758
chr16:2,751,637–2,753,398 214.5 kb Distal (>10kb) Multiome 1074
chr16:2,776,766–2,778,256 239.3 kb Distal (>10kb) Multiome 828

Genome Browser

Genomic view of the PDPK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr16:2,241,044 – 2,788,256
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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