Enables alpha-actinin binding activity; protein homodimerization activity; and protein phosphatase binding activity. Involved in actin cytoskeleton organization. Located in several cellular components, including lamellipodium; perinuclear region of cytoplasm; and stress fiber. Part of filamentous actin. Implicated in osteoporosis. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PDLIM4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDLIM4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDLIM4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:132,003,192–132,003,913 | 254.2 kb | Distal (>10kb) Multiome | 421 | |
| chr5:132,010,633–132,012,365 | 246.0 kb | Distal (>10kb) Multiome | 361 | |
| chr5:132,226,810–132,228,575 | 29.8 kb | Distal (>10kb) Multiome | 725 | |
| chr5:132,256,858–132,258,371 | 114 bp | At TSS Multiome | 338 | |
| chr5:132,293,061–132,295,661 | 36.5 kb | Distal (>10kb) Multiome | 1053 | |
| chr5:132,369,150–132,370,578 | 112.0 kb | Distal (>10kb) Multiome | 819 | |
| chr5:132,410,330–132,411,433 | 153.3 kb | Distal (>10kb) Multiome | 815 | |
| chr5:132,419,541–132,419,986 | 162.1 kb | Distal (>10kb) Multiome | 481 | |
| chr5:132,426,660–132,427,851 | 169.4 kb | Distal (>10kb) Multiome | 540 | |
| chr5:132,489,909–132,492,004 | 233.2 kb | Distal (>10kb) Multiome | 899 | |
| chr5:132,495,550–132,497,614 | 238.7 kb | Distal (>10kb) Multiome | 946 | |
| chr5:132,526,534–132,527,026 | 269.1 kb | Distal (>10kb) Multiome | 329 | |
| chr5:132,556,575–132,557,723 | 299.3 kb | Distal (>10kb) Multiome | 1071 |
Genomic view of the PDLIM4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.