The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy. [provided by RefSeq, Apr 2012]
Transcription factors with Perturb-seq knockdown data for PDLIM3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDLIM3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDLIM3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:185,235,783–185,236,350 | 299.5 kb | Distal (>10kb) Multiome | 289 | |
| chr4:185,318,614–185,319,089 | 216.6 kb | Distal (>10kb) Multiome | 382 | |
| chr4:185,395,863–185,397,395 | 138.9 kb | Distal (>10kb) Multiome | 1140 | |
| chr4:185,425,371–185,426,547 | 109.4 kb | Distal (>10kb) Multiome | 873 | |
| chr4:185,470,476–185,472,157 | 64.1 kb | Distal (>10kb) Multiome | 628 | |
| chr4:185,534,729–185,535,832 | 64 bp | At TSS Multiome | 535 | |
| chr4:185,559,542–185,560,280 | 24.4 kb | Distal (>10kb) Multiome | 164 | |
| chr4:185,650,774–185,651,628 | 115.7 kb | Distal (>10kb) Multiome | 184 |
Genomic view of the PDLIM3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.