The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]
Transcription factors with Perturb-seq knockdown data for PDE7A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDE7A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDE7A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:65,560,267–65,560,834 | 281.5 kb | Distal (>10kb) Multiome | 210 | |
| chr8:65,633,786–65,634,726 | 207.8 kb | Distal (>10kb) Multiome | 837 | |
| chr8:65,643,517–65,645,623 | 197.3 kb | Distal (>10kb) Multiome | 852 | |
| chr8:65,840,608–65,843,127 | 221 bp | At TSS Multiome | 1129 | |
| chr8:66,112,392–66,115,016 | 271.2 kb | Distal (>10kb) Multiome | 1099 |
Genomic view of the PDE7A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.