Enables 3',5'-cyclic-AMP phosphodiesterase activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of lipid catabolic process; and regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in membrane. Part of guanyl-nucleotide exchange factor complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PDE3B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDE3B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDE3B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:14,357,756–14,359,493 | 284.8 kb | Distal (>10kb) Multiome | 664 | |
| chr11:14,380,905–14,381,570 | 262.6 kb | Distal (>10kb) Multiome | 501 | |
| chr11:14,499,208–14,500,395 | 144.0 kb | Distal (>10kb) Multiome | 813 | |
| chr11:14,519,723–14,521,072 | 123.4 kb | Distal (>10kb) Multiome | 1010 | |
| chr11:14,633,489–14,633,994 | 9.8 kb | Proximal (<10kb) | 65 | |
| chr11:14,643,085–14,645,138 | 28 bp | At TSS Multiome | 880 | |
| chr11:14,791,132–14,791,866 | 147.7 kb | Distal (>10kb) Multiome | 119 | |
| chr11:14,855,765–14,856,853 | 212.4 kb | Distal (>10kb) Multiome | 173 | |
| chr11:14,886,335–14,887,322 | 242.9 kb | Distal (>10kb) Multiome | 149 | |
| chr11:14,890,942–14,892,679 | 248.4 kb | Distal (>10kb) Multiome | 910 | |
| chr11:14,904,700–14,906,451 | 261.7 kb | Distal (>10kb) Multiome | 355 | |
| chr11:14,907,367–14,908,221 | 264.0 kb | Distal (>10kb) Multiome | 310 |
Genomic view of the PDE3B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.