Enables poly(A)-specific ribonuclease activity. Involved in several processes, including cellular response to interferon-alpha; innate immune response; and mRNA catabolic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PDE12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDE12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDE12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:57,169,750–57,170,529 | 386.0 kb | Distal (>10kb) Multiome HiCAR | 491 | |
| chr3:57,543,921–57,544,886 | 11.9 kb | Distal (>10kb) Multiome | 280 | |
| chr3:57,546,064–57,547,149 | 9.5 kb | Proximal (<10kb) Multiome | 113 | |
| chr3:57,555,739–57,556,867 | 125 bp | At TSS Multiome | 1030 | |
| chr3:57,596,484–57,598,208 | 41.3 kb | Distal (>10kb) Multiome | 936 | |
| chr3:57,692,365–57,693,415 | 136.7 kb | Distal (>10kb) Multiome | 923 | |
| chr3:57,727,873–57,728,338 | 171.8 kb | Distal (>10kb) Multiome | 20 | |
| chr3:57,755,657–57,757,330 | 199.9 kb | Distal (>10kb) Multiome | 930 |
Genomic view of the PDE12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.