This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PDCL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDCL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDCL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:100,321,138–100,322,670 | 241.4 kb | Distal (>10kb) Multiome | 420 | |
| chr2:100,416,735–100,417,903 | 145.4 kb | Distal (>10kb) Multiome | 713 | |
| chr2:100,561,925–100,563,639 | 7 bp | At TSS Multiome | 976 | |
| chr2:100,639,460–100,640,170 | 76.8 kb | Distal (>10kb) Multiome | 46 | |
| chr2:100,819,224–100,821,156 | 257.2 kb | Distal (>10kb) Multiome | 577 |
Genomic view of the PDCL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.