PDCD11 is a NF-kappa-B (NFKB1; 164011)-binding protein that colocalizes with U3 RNA (MIM 180710) in the nucleolus and is required for rRNA maturation and generation of 18S rRNA (Sweet et al., 2003 [PubMed 14624448]; Sweet et al., 2008 [PubMed 17654514]).[supplied by OMIM, Oct 2008]
Transcription factors with Perturb-seq knockdown data for PDCD11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDCD11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDCD11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:103,192,518–103,193,861 | 203.4 kb | Distal (>10kb) Multiome | 725 | |
| chr10:103,204,930–103,206,025 | 191.6 kb | Distal (>10kb) Multiome | 207 | |
| chr10:103,206,729–103,207,578 | 189.4 kb | Distal (>10kb) Multiome | 46 | |
| chr10:103,276,757–103,278,251 | 119.3 kb | Distal (>10kb) Multiome | 385 | |
| chr10:103,350,520–103,351,294 | 45.6 kb | Distal (>10kb) Multiome | 679 | |
| chr10:103,367,765–103,368,860 | 28.0 kb | Distal (>10kb) Multiome | 925 | |
| chr10:103,395,952–103,396,926 | 79 bp | At TSS Multiome | 821 | |
| chr10:103,493,310–103,494,526 | 97.0 kb | Distal (>10kb) Multiome | 299 | |
| chr10:103,542,810–103,543,379 | 146.5 kb | Distal (>10kb) Multiome | 294 | |
| chr10:103,661,427–103,661,981 | 265.0 kb | Distal (>10kb) Multiome | 301 | |
| chr10:103,692,163–103,693,782 | 295.7 kb | Distal (>10kb) Multiome | 288 |
Genomic view of the PDCD11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.