This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. The protease is expressed only in the testis, placenta, and ovary. It plays a critical role in fertilization, fetoplacental growth, and embryonic development and processes multiple prohormones including pro-pituitary adenylate cyclase-activating protein and pro-insulin-like growth factor II. [provided by RefSeq, Jan 2014]
Transcription factors with Perturb-seq knockdown data for PCSK4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PCSK4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PCSK4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:1,194,370–1,194,985 | 295.7 kb | Distal (>10kb) Multiome | 531 | |
| chr19:1,205,175–1,206,374 | 284.8 kb | Distal (>10kb) Multiome | 746 | |
| chr19:1,237,080–1,238,434 | 252.3 kb | Distal (>10kb) Multiome | 430 | |
| chr19:1,239,513–1,242,539 | 248.6 kb | Distal (>10kb) Multiome | 889 | |
| chr19:1,244,253–1,244,857 | 245.8 kb | Distal (>10kb) Multiome | 590 | |
| chr19:1,247,981–1,252,501 | 239.3 kb | Distal (>10kb) Multiome | 1136 | |
| chr19:1,259,185–1,262,955 | 231.0 kb | Distal (>10kb) Multiome | 1070 | |
| chr19:1,265,280–1,270,235 | 221.1 kb | Distal (>10kb) Multiome | 1171 | |
| chr19:1,274,423–1,276,502 | 214.6 kb | Distal (>10kb) Multiome | 967 | |
| chr19:1,285,317–1,286,108 | 204.6 kb | Distal (>10kb) Multiome | 277 | |
| chr19:1,354,303–1,355,411 | 135.5 kb | Distal (>10kb) Multiome | 688 | |
| chr19:1,383,122–1,384,333 | 106.7 kb | Distal (>10kb) Multiome | 1228 | |
| chr19:1,401,101–1,401,839 | 88.8 kb | Distal (>10kb) Multiome | 540 | |
| chr19:1,406,589–1,408,783 | 83.0 kb | Distal (>10kb) Multiome | 911 | |
| chr19:1,415,008–1,415,721 | 74.9 kb | Distal (>10kb) Multiome | 597 | |
| chr19:1,437,988–1,438,998 | 52.0 kb | Distal (>10kb) Multiome | 1076 | |
| chr19:1,444,785–1,447,383 | 45.1 kb | Distal (>10kb) Multiome | 797 | |
| chr19:1,455,191–1,456,421 | 34.6 kb | Distal (>10kb) Multiome | 491 | |
| chr19:1,470,088–1,471,597 | 19.6 kb | Distal (>10kb) Multiome | 544 | |
| chr19:1,478,772–1,479,848 | 11.0 kb | Distal (>10kb) Multiome | 857 | |
| chr19:1,489,566–1,491,829 | 500 bp | At TSS Multiome | 836 | |
| chr19:1,507,230–1,508,699 | 17.7 kb | Distal (>10kb) Multiome | 596 | |
| chr19:1,512,960–1,513,686 | 22.8 kb | Distal (>10kb) Multiome | 541 | |
| chr19:1,523,798–1,524,624 | 33.7 kb | Distal (>10kb) Multiome | 263 | |
| chr19:1,566,277–1,568,916 | 76.4 kb | Distal (>10kb) Multiome | 748 | |
| chr19:1,592,085–1,593,444 | 102.4 kb | Distal (>10kb) Multiome | 883 | |
| chr19:1,604,859–1,606,501 | 115.3 kb | Distal (>10kb) Multiome | 902 | |
| chr19:1,651,519–1,653,514 | 162.6 kb | Distal (>10kb) Multiome | 909 | |
| chr19:1,725,307–1,726,101 | 235.4 kb | Distal (>10kb) Multiome | 455 | |
| chr19:1,811,638–1,813,347 | 322.2 kb | Distal (>10kb) Multiome HiCAR | 782 |
Genomic view of the PCSK4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.