This gene encodes an evolutionarily conserved transmembrane protein similar to the pecanex protein in Drosophila. The fly protein is a component of the Notch signaling pathway, which functions in several developmental processes. [provided by RefSeq, Jul 2016]
Transcription factors with Perturb-seq knockdown data for PCNX1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PCNX1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PCNX1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:70,641,239–70,642,585 | 265.9 kb | Distal (>10kb) Multiome | 486 | |
| chr14:70,716,516–70,717,866 | 190.6 kb | Distal (>10kb) Multiome | 256 | |
| chr14:70,753,481–70,754,035 | 153.9 kb | Distal (>10kb) Multiome | 262 | |
| chr14:70,808,217–70,810,598 | 97.9 kb | Distal (>10kb) Multiome | 697 | |
| chr14:70,817,332–70,818,017 | 89.8 kb | Distal (>10kb) Multiome | 483 | |
| chr14:70,821,689–70,823,208 | 84.8 kb | Distal (>10kb) Multiome | 559 | |
| chr14:70,907,022–70,908,784 | 201 bp | At TSS Multiome | 716 | |
| chr14:71,129,419–71,131,060 | 222.4 kb | Distal (>10kb) Multiome | 219 |
Genomic view of the PCNX1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.