The protein encoded by this gene is a member of the GDSL/SGNH superfamily. Members of this family are hydrolytic enzymes with esterase and lipase activity and broad substrate specificity. This protein belongs to the Pmr5-Cas1p-esterase subfamily in that it contains the catalytic triad comprised of serine, aspartate and histidine and lacks two conserved regions (glycine after strand S2 and GxND motif). A pseudogene of this gene has been identified on the long arm of chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Sep 2012]
Transcription factors with Perturb-seq knockdown data for PCED1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PCED1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PCED1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:2,651,802–2,653,286 | 188.1 kb | Distal (>10kb) Multiome | 1060 | |
| chr20:2,663,925–2,664,409 | 176.4 kb | Distal (>10kb) Multiome | 908 | |
| chr20:2,692,159–2,694,013 | 148.0 kb | Distal (>10kb) Multiome | 584 | |
| chr20:2,800,326–2,801,021 | 39.9 kb | Distal (>10kb) Multiome | 349 | |
| chr20:2,840,006–2,841,330 | 2 bp | At TSS Multiome | 997 | |
| chr20:2,872,329–2,874,047 | 32.9 kb | Distal (>10kb) Multiome | 980 | |
| chr20:3,045,415–3,046,996 | 205.3 kb | Distal (>10kb) Multiome | 999 | |
| chr20:3,071,569–3,072,466 | 231.5 kb | Distal (>10kb) Multiome | 214 | |
| chr20:3,092,619–3,093,442 | 252.4 kb | Distal (>10kb) Multiome | 180 |
Genomic view of the PCED1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.