PARP14

poly(ADP-ribose) polymerase family member 14 | ARTD8, BAL2, KIAA1268, pART8

This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of cancer cells. Increased expression of this gene has been reported in a variety of tumor types. [provided by RefSeq, Jul 2016]

Member of: DE-5 DE-5.2

Biological processes 32 terms

NAD+ binding (GO:0070403)NAD+ binding (GO:0070403)NAD+ catabolic process (GO:0019677)NAD+ poly-ADP-ribosyltransferase activity (GO:0003950)NAD+ poly-ADP-ribosyltransferase activity (GO:0003950)NAD+ poly-ADP-ribosyltransferase activity (GO:0003950)NAD+ poly-ADP-ribosyltransferase activity (GO:0003950)NAD+-protein mono-ADP-ribosyltransferase activity (GO:1990404)NAD+-protein mono-ADP-ribosyltransferase activity (GO:1990404)NAD+-protein-glutamate ADP-ribosyltransferase activity (GO:0140807)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)enzyme binding (GO:0019899)membrane (GO:0016020)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of gene expression (GO:0010629)negative regulation of gene expression (GO:0010629)negative regulation of type II interferon-mediated signaling pathway (GO:0060336)negative regulation of type II interferon-mediated signaling pathway (GO:0060336)negative regulation of type II interferon-mediated signaling pathway (GO:0060336)negative regulation of tyrosine phosphorylation of STAT protein (GO:0042532)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of interleukin-4-mediated signaling pathway (GO:1902216)positive regulation of interleukin-4-mediated signaling pathway (GO:1902216)positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)protein binding (GO:0005515)protein poly-ADP-ribosylation (GO:0070212)protein poly-ADP-ribosylation (GO:0070212)transcription corepressor activity (GO:0003714)

Expression (TPM)

TFs regulating PARP14 0 TFs

Transcription factors with Perturb-seq knockdown data for PARP14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PARP14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PARP14

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PARP14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr3:122,382,880–122,383,692	297.8 kb	Distal (>10kb) Multiome	711
chr3:122,383,843–122,384,747	296.6 kb	Distal (>10kb) Multiome	937
chr3:122,442,936–122,443,707	237.5 kb	Distal (>10kb) Multiome	134
chr3:122,514,019–122,515,266	166.0 kb	Distal (>10kb) Multiome HiCAR	888
chr3:122,564,086–122,564,854	116.4 kb	Distal (>10kb) Multiome	849
chr3:122,679,167–122,679,828	1.0 kb	Proximal (<10kb)	357
chr3:122,680,509–122,681,348	169 bp	At TSS Multiome	567
chr3:122,798,643–122,799,856	118.4 kb	Distal (>10kb) Multiome	131
chr3:122,890,181–122,890,667	209.5 kb	Distal (>10kb) Multiome	154
chr3:122,942,761–122,943,436	262.3 kb	Distal (>10kb) Multiome	336
chr3:122,975,104–122,975,992	294.7 kb	Distal (>10kb) Multiome	338

Genome Browser

Genomic view of the PARP14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.