Enables NAD+-protein mono-ADP-ribosyltransferase activity. Involved in protein auto-ADP-ribosylation. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PARP12. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PARP12 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PARP12, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:139,777,264–139,778,898 | 284.9 kb | Distal (>10kb) Multiome | 657 | |
| chr7:139,971,936–139,972,384 | 90.8 kb | Distal (>10kb) Multiome | 102 | |
| chr7:140,062,257–140,063,368 | 29 bp | At TSS Multiome | 805 | |
| chr7:140,175,218–140,177,799 | 112.6 kb | Distal (>10kb) Multiome | 1056 | |
| chr7:140,229,607–140,231,952 | 168.5 kb | Distal (>10kb) Multiome | 914 |
Genomic view of the PARP12 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.