The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PARK7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PARK7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PARK7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:7,667,425–7,668,031 | 293.9 kb | Distal (>10kb) Multiome HiCAR | 391 | |
| chr1:7,669,374–7,669,989 | 291.9 kb | Distal (>10kb) Multiome HiCAR | 285 | |
| chr1:7,680,111–7,680,720 | 281.2 kb | Distal (>10kb) Multiome | 466 | |
| chr1:7,703,734–7,704,990 | 257.0 kb | Distal (>10kb) Multiome | 419 | |
| chr1:7,770,840–7,771,872 | 190.4 kb | Distal (>10kb) Multiome | 711 | |
| chr1:7,783,377–7,785,071 | 177.7 kb | Distal (>10kb) Multiome | 618 | |
| chr1:7,885,362–7,886,254 | 75.9 kb | Distal (>10kb) Multiome | 196 | |
| chr1:7,942,207–7,942,705 | 19.2 kb | Distal (>10kb) Multiome | 315 | |
| chr1:7,953,925–7,954,593 | 7.4 kb | Proximal (<10kb) Multiome | 708 | |
| chr1:7,960,714–7,960,895 | 766 bp | At TSS | 34 | |
| chr1:7,961,111–7,962,145 | 64 bp | At TSS Multiome | 1012 | |
| chr1:8,004,118–8,005,226 | 43.1 kb | Distal (>10kb) Multiome | 617 | |
| chr1:8,025,593–8,027,129 | 64.7 kb | Distal (>10kb) Multiome | 938 | |
| chr1:8,083,702–8,084,519 | 122.6 kb | Distal (>10kb) Multiome | 382 | |
| chr1:8,107,730–8,108,244 | 146.4 kb | Distal (>10kb) Multiome | 104 | |
| chr1:8,166,706–8,167,855 | 205.7 kb | Distal (>10kb) Multiome | 348 | |
| chr1:8,216,976–8,217,707 | 255.6 kb | Distal (>10kb) Multiome | 224 |
Genomic view of the PARK7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.