Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
Transcription factors with Perturb-seq knockdown data for PARG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PARG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PARG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:49,679,268–49,679,978 | 262.4 kb | Distal (>10kb) Multiome | 295 | |
| chr10:49,689,972–49,690,461 | 251.7 kb | Distal (>10kb) Multiome | 90 | |
| chr10:49,761,560–49,762,540 | 179.7 kb | Distal (>10kb) Multiome | 910 | |
| chr10:49,767,863–49,769,213 | 173.3 kb | Distal (>10kb) Multiome | 132 | |
| chr10:49,932,053–49,932,292 | 9.7 kb | Proximal (<10kb) | 5 | |
| chr10:49,941,526–49,942,344 | 20 bp | At TSS Multiome | 478 | |
| chr10:50,067,797–50,068,365 | 126.0 kb | Distal (>10kb) Multiome | 393 |
Genomic view of the PARG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.