This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PARD6B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PARD6B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PARD6B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:50,509,813–50,510,874 | 221.3 kb | Distal (>10kb) Multiome | 1005 | |
| chr20:50,635,765–50,636,791 | 95.5 kb | Distal (>10kb) Multiome | 720 | |
| chr20:50,641,661–50,642,825 | 89.1 kb | Distal (>10kb) Multiome | 190 | |
| chr20:50,645,216–50,645,868 | 85.9 kb | Distal (>10kb) Multiome | 792 | |
| chr20:50,724,920–50,725,366 | 6.2 kb | Proximal (<10kb) | 504 | |
| chr20:50,730,245–50,732,382 | 320 bp | At TSS Multiome | 1014 | |
| chr20:50,767,314–50,767,756 | 35.9 kb | Distal (>10kb) Multiome | 140 | |
| chr20:50,790,529–50,791,153 | 59.3 kb | Distal (>10kb) Multiome | 980 | |
| chr20:50,794,408–50,795,648 | 63.4 kb | Distal (>10kb) Multiome | 794 | |
| chr20:50,818,246–50,818,886 | 87.0 kb | Distal (>10kb) Multiome | 844 | |
| chr20:50,870,405–50,871,527 | 139.4 kb | Distal (>10kb) Multiome | 254 | |
| chr20:50,930,214–50,932,320 | 200.1 kb | Distal (>10kb) Multiome | 1082 | |
| chr20:50,958,262–50,959,227 | 227.1 kb | Distal (>10kb) Multiome | 929 | |
| chr20:50,992,251–50,993,606 | 261.6 kb | Distal (>10kb) Multiome | 409 | |
| chr20:51,022,526–51,023,913 | 291.7 kb | Distal (>10kb) Multiome | 437 |
Genomic view of the PARD6B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.