Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in several processes, including establishment of cell polarity; establishment of centrosome localization; and establishment or maintenance of epithelial cell apical/basal polarity. Located in cell junction. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PARD3B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PARD3B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PARD3B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:204,263,937–204,264,703 | 281.1 kb | Distal (>10kb) Multiome HiCAR | 203 | |
| chr2:204,282,244–204,282,902 | 262.8 kb | Distal (>10kb) Multiome | 152 | |
| chr2:204,538,294–204,538,770 | 6.7 kb | Proximal (<10kb) | 183 | |
| chr2:204,544,948–204,546,447 | 67 bp | At TSS Multiome | 664 | |
| chr2:204,548,856–204,549,754 | 3.9 kb | Proximal (<10kb) Multiome | 152 |
Genomic view of the PARD3B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.