Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PAPSS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PAPSS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PAPSS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:87,504,459–87,505,741 | 154.7 kb | Distal (>10kb) Multiome | 833 | |
| chr10:87,651,913–87,652,094 | 7.5 kb | Proximal (<10kb) | 47 | |
| chr10:87,656,559–87,656,745 | 2.9 kb | Proximal (<10kb) | 131 | |
| chr10:87,658,548–87,660,459 | 294 bp | At TSS Multiome | 507 | |
| chr10:87,734,828–87,735,531 | 75.6 kb | Distal (>10kb) Multiome | 289 | |
| chr10:87,817,687–87,819,379 | 158.6 kb | Distal (>10kb) Multiome | 867 | |
| chr10:87,861,521–87,864,430 | 203.9 kb | Distal (>10kb) Multiome | 1208 | |
| chr10:87,915,332–87,915,810 | 256.0 kb | Distal (>10kb) Multiome | 128 |
Genomic view of the PAPSS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.