The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 1 are abundantly expressed in central nervous system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 1 may form cell type-specific gap junctions with distinct properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Transcription factors with Perturb-seq knockdown data for PANX2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PANX2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PANX2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:49,917,887–49,919,285 | 252.3 kb | Distal (>10kb) Multiome | 736 | |
| chr22:49,935,964–49,936,517 | 234.7 kb | Distal (>10kb) Multiome | 637 | |
| chr22:49,959,889–49,961,612 | 210.3 kb | Distal (>10kb) Multiome | 843 | |
| chr22:49,961,773–49,962,968 | 208.3 kb | Distal (>10kb) Multiome | 708 | |
| chr22:49,999,173–50,000,437 | 171.1 kb | Distal (>10kb) Multiome | 237 | |
| chr22:50,030,288–50,030,739 | 140.3 kb | Distal (>10kb) Multiome | 433 | |
| chr22:50,169,918–50,170,446 | 541 bp | At TSS Multiome | 245 | |
| chr22:50,170,597–50,171,052 | at TSS | At TSS | 136 | |
| chr22:50,184,288–50,186,776 | 15.1 kb | Distal (>10kb) Multiome | 542 | |
| chr22:50,199,706–50,201,679 | 30.2 kb | Distal (>10kb) Multiome | 612 | |
| chr22:50,244,340–50,245,635 | 74.3 kb | Distal (>10kb) Multiome | 868 | |
| chr22:50,250,480–50,251,917 | 80.6 kb | Distal (>10kb) Multiome | 683 | |
| chr22:50,261,070–50,261,932 | 90.9 kb | Distal (>10kb) Multiome | 512 | |
| chr22:50,267,469–50,268,208 | 97.0 kb | Distal (>10kb) Multiome | 196 | |
| chr22:50,299,702–50,300,750 | 129.6 kb | Distal (>10kb) Multiome | 250 | |
| chr22:50,307,140–50,307,760 | 136.8 kb | Distal (>10kb) Multiome | 392 | |
| chr22:50,326,615–50,327,631 | 156.3 kb | Distal (>10kb) Multiome | 754 | |
| chr22:50,342,153–50,342,608 | 171.7 kb | Distal (>10kb) Multiome | 553 | |
| chr22:50,342,772–50,343,603 | 172.4 kb | Distal (>10kb) Multiome | 573 |
Genomic view of the PANX2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.