This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is expressed most abundantly in the liver. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PANK3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PANK3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PANK3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:168,291,138–168,293,102 | 287.7 kb | Distal (>10kb) Multiome | 633 | |
| chr5:168,295,589–168,296,149 | 283.6 kb | Distal (>10kb) Multiome | 209 | |
| chr5:168,328,780–168,329,633 | 250.2 kb | Distal (>10kb) Multiome | 243 | |
| chr5:168,334,311–168,335,028 | 244.6 kb | Distal (>10kb) Multiome | 189 | |
| chr5:168,486,057–168,486,891 | 92.9 kb | Distal (>10kb) Multiome | 846 | |
| chr5:168,528,975–168,529,622 | 50.1 kb | Distal (>10kb) Multiome | 229 | |
| chr5:168,578,780–168,580,390 | 314 bp | At TSS Multiome | 938 | |
| chr5:168,580,861–168,581,396 | 1.8 kb | Proximal (<10kb) Multiome | 158 |
Genomic view of the PANK3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.