Transcription factors with Perturb-seq knockdown data for PANK2-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PANK2-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PANK2-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:3,672,530–3,673,055 | 216.5 kb | Distal (>10kb) Multiome | 158 | |
| chr20:3,681,778–3,682,557 | 207.0 kb | Distal (>10kb) Multiome | 170 | |
| chr20:3,732,150–3,733,030 | 156.6 kb | Distal (>10kb) Multiome | 192 | |
| chr20:3,744,813–3,745,795 | 144.0 kb | Distal (>10kb) Multiome | 379 | |
| chr20:3,749,619–3,750,251 | 139.2 kb | Distal (>10kb) Multiome | 520 | |
| chr20:3,751,352–3,752,738 | 137.0 kb | Distal (>10kb) Multiome | 261 | |
| chr20:3,767,155–3,768,879 | 121.3 kb | Distal (>10kb) Multiome | 1011 | |
| chr20:3,777,516–3,778,624 | 111.0 kb | Distal (>10kb) Multiome | 428 | |
| chr20:3,781,161–3,781,797 | 107.7 kb | Distal (>10kb) Multiome | 595 | |
| chr20:3,785,713–3,787,025 | 102.4 kb | Distal (>10kb) Multiome | 695 | |
| chr20:3,795,543–3,796,972 | 93.1 kb | Distal (>10kb) Multiome | 925 | |
| chr20:3,799,527–3,800,087 | 89.4 kb | Distal (>10kb) Multiome | 197 | |
| chr20:3,820,073–3,821,115 | 68.7 kb | Distal (>10kb) Multiome | 1081 | |
| chr20:3,846,214–3,847,496 | 42.4 kb | Distal (>10kb) Multiome | 940 | |
| chr20:3,875,544–3,876,019 | 13.3 kb | Distal (>10kb) Multiome | 80 | |
| chr20:3,888,329–3,890,033 | 27 bp | At TSS Multiome | 1031 | |
| chr20:4,014,730–4,016,019 | 126.4 kb | Distal (>10kb) Multiome | 865 | |
| chr20:4,064,484–4,064,955 | 175.5 kb | Distal (>10kb) Multiome | 290 | |
| chr20:4,082,773–4,083,490 | 194.0 kb | Distal (>10kb) Multiome | 445 | |
| chr20:4,085,118–4,085,823 | 196.3 kb | Distal (>10kb) Multiome | 674 | |
| chr20:4,108,490–4,109,121 | 219.6 kb | Distal (>10kb) Multiome | 600 | |
| chr20:4,148,342–4,150,081 | 259.6 kb | Distal (>10kb) Multiome | 657 | |
| chr20:4,165,766–4,166,634 | 276.9 kb | Distal (>10kb) Multiome | 108 | |
| chr20:4,171,885–4,173,010 | 283.4 kb | Distal (>10kb) Multiome | 928 |
Genomic view of the PANK2-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.