Transcription factors with Perturb-seq knockdown data for PANCR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PANCR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PANCR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:110,411,354–110,412,301 | 203.8 kb | Distal (>10kb) Multiome | 372 | |
| chr4:110,609,129–110,609,424 | 6.0 kb | Proximal (<10kb) | 111 | |
| chr4:110,613,796–110,614,882 | 1.3 kb | Proximal (<10kb) Multiome | 225 | |
| chr4:110,615,006–110,616,645 | 253 bp | At TSS Multiome | 226 | |
| chr4:110,617,892–110,620,263 | 4.0 kb | Proximal (<10kb) Multiome | 335 | |
| chr4:110,620,638–110,627,477 | 7.5 kb | Proximal (<10kb) Multiome | 562 | |
| chr4:110,630,610–110,633,369 | 15.2 kb | Distal (>10kb) Multiome | 525 | |
| chr4:110,793,382–110,794,932 | 178.8 kb | Distal (>10kb) Multiome | 287 |
Genomic view of the PANCR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.