Predicted to enable protein tyrosine phosphatase activity. Located in cytosol and intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for PALD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PALD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PALD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:70,232,204–70,234,260 | 245.2 kb | Distal (>10kb) Multiome | 949 | |
| chr10:70,381,835–70,383,091 | 96.1 kb | Distal (>10kb) Multiome | 693 | |
| chr10:70,403,687–70,404,709 | 74.7 kb | Distal (>10kb) Multiome | 788 | |
| chr10:70,437,649–70,438,147 | 40.8 kb | Distal (>10kb) Multiome | 93 | |
| chr10:70,439,787–70,443,007 | 36.1 kb | Distal (>10kb) Multiome | 501 | |
| chr10:70,455,031–70,455,839 | 23.3 kb | Distal (>10kb) Multiome | 196 | |
| chr10:70,458,264–70,459,984 | 20.2 kb | Distal (>10kb) Multiome | 310 | |
| chr10:70,478,010–70,479,323 | 59 bp | At TSS Multiome | 492 | |
| chr10:70,672,118–70,672,962 | 193.8 kb | Distal (>10kb) Multiome | 465 |
Genomic view of the PALD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.