This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PALB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PALB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PALB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:23,452,612–23,453,515 | 188.3 kb | Distal (>10kb) Multiome | 1008 | |
| chr16:23,509,880–23,510,853 | 130.9 kb | Distal (>10kb) Multiome | 947 | |
| chr16:23,557,038–23,558,356 | 83.8 kb | Distal (>10kb) Multiome | 1119 | |
| chr16:23,595,873–23,596,693 | 45.0 kb | Distal (>10kb) Multiome | 938 | |
| chr16:23,640,088–23,640,480 | 1.2 kb | Proximal (<10kb) Multiome | 169 | |
| chr16:23,641,019–23,641,779 | 117 bp | At TSS Multiome | 1055 | |
| chr16:23,678,415–23,679,119 | 37.5 kb | Distal (>10kb) Multiome | 878 | |
| chr16:23,694,678–23,695,256 | 53.7 kb | Distal (>10kb) Multiome | 456 | |
| chr16:23,835,511–23,836,674 | 194.6 kb | Distal (>10kb) Multiome | 420 |
Genomic view of the PALB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.