Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for PAIP2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PAIP2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PAIP2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:70,976,676–70,977,663 | 249.8 kb | Distal (>10kb) Multiome | 372 | |
| chr2:70,978,404–70,979,416 | 248.1 kb | Distal (>10kb) Multiome | 229 | |
| chr2:70,994,406–70,995,235 | 232.1 kb | Distal (>10kb) Multiome | 805 | |
| chr2:71,067,597–71,069,479 | 158.6 kb | Distal (>10kb) Multiome | 1161 | |
| chr2:71,103,036–71,103,639 | 123.7 kb | Distal (>10kb) Multiome | 56 | |
| chr2:71,129,728–71,130,863 | 96.7 kb | Distal (>10kb) Multiome | 1092 | |
| chr2:71,226,288–71,227,849 | 207 bp | At TSS Multiome | 657 | |
| chr2:71,276,206–71,277,158 | 49.5 kb | Distal (>10kb) Multiome | 790 | |
| chr2:71,331,200–71,332,517 | 104.7 kb | Distal (>10kb) Multiome | 920 | |
| chr2:71,453,379–71,454,558 | 226.6 kb | Distal (>10kb) Multiome | 298 | |
| chr2:71,466,113–71,467,114 | 239.6 kb | Distal (>10kb) Multiome | 334 |
Genomic view of the PAIP2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.