The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PAIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PAIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PAIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:43,312,549–43,314,340 | 243.5 kb | Distal (>10kb) Multiome | 954 | |
| chr5:43,348,196–43,348,656 | 208.7 kb | Distal (>10kb) Multiome | 141 | |
| chr5:43,396,804–43,397,322 | 159.9 kb | Distal (>10kb) Multiome | 340 | |
| chr5:43,416,225–43,416,784 | 140.6 kb | Distal (>10kb) Multiome | 263 | |
| chr5:43,483,333–43,484,741 | 73.2 kb | Distal (>10kb) Multiome | 1033 | |
| chr5:43,514,568–43,515,502 | 41.9 kb | Distal (>10kb) Multiome | 817 | |
| chr5:43,553,232–43,554,155 | 2.2 kb | Proximal (<10kb) | 92 | |
| chr5:43,555,878–43,557,718 | 181 bp | At TSS Multiome | 936 | |
| chr5:43,602,369–43,604,281 | 46.0 kb | Distal (>10kb) Multiome | 912 | |
| chr5:44,506,221–44,506,892 | 949.6 kb | Distal (>10kb) Multiome HiCAR | 207 | |
| chr5:44,638,090–44,639,138 | 1081.5 kb | Distal (>10kb) Multiome HiCAR | 164 |
Genomic view of the PAIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.