This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PAICS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PAICS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PAICS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:56,323,870–56,324,663 | 111.9 kb | Distal (>10kb) Multiome | 70 | |
| chr4:56,386,710–56,387,993 | 48.9 kb | Distal (>10kb) Multiome | 942 | |
| chr4:56,434,804–56,437,263 | 336 bp | At TSS Multiome | 1056 | |
| chr4:56,467,264–56,468,300 | 31.4 kb | Distal (>10kb) Multiome | 743 | |
| chr4:56,505,059–56,505,907 | 69.3 kb | Distal (>10kb) Multiome | 306 | |
| chr4:56,530,151–56,531,207 | 94.3 kb | Distal (>10kb) Multiome | 395 | |
| chr4:56,544,602–56,545,190 | 108.5 kb | Distal (>10kb) Multiome | 720 | |
| chr4:56,655,262–56,656,591 | 219.4 kb | Distal (>10kb) Multiome | 237 |
Genomic view of the PAICS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.