Enables protein phosphatase 2A binding activity and protein serine/threonine phosphatase inhibitor activity. Involved in mitotic G2/M transition checkpoint; positive regulation of cell growth; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in cytoplasm and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PABIR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PABIR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PABIR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:68,704,523–68,706,504 | 74.8 kb | Distal (>10kb) Multiome | 702 | |
| chr9:68,755,540–68,756,160 | 24.1 kb | Distal (>10kb) Multiome | 164 | |
| chr9:68,779,458–68,780,758 | 15 bp | At TSS Multiome | 827 | |
| chr9:68,871,983–68,872,511 | 92.2 kb | Distal (>10kb) Multiome | 208 | |
| chr9:68,894,403–68,895,261 | 114.7 kb | Distal (>10kb) Multiome | 84 | |
| chr9:69,035,618–69,036,298 | 255.8 kb | Distal (>10kb) Multiome | 819 |
Genomic view of the PABIR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.