This gene encodes a WD repeat-containing protein involved in regulation of association of proteasome components. During HIV infection, the encoded protein is thought to promote provirus transcription through recruitment of the 19S regulatory complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]
Transcription factors with Perturb-seq knockdown data for PAAF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PAAF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PAAF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:73,597,688–73,598,911 | 278.7 kb | Distal (>10kb) Multiome | 887 | |
| chr11:73,645,683–73,646,788 | 230.8 kb | Distal (>10kb) Multiome | 193 | |
| chr11:73,647,445–73,647,968 | 229.4 kb | Distal (>10kb) Multiome | 442 | |
| chr11:73,660,644–73,661,627 | 215.8 kb | Distal (>10kb) Multiome | 525 | |
| chr11:73,760,242–73,761,712 | 115.8 kb | Distal (>10kb) Multiome | 842 | |
| chr11:73,779,162–73,780,136 | 97.4 kb | Distal (>10kb) Multiome | 920 | |
| chr11:73,787,771–73,788,337 | 88.9 kb | Distal (>10kb) Multiome | 1000 | |
| chr11:73,876,432–73,877,378 | 125 bp | At TSS Multiome | 911 | |
| chr11:73,982,330–73,983,905 | 106.1 kb | Distal (>10kb) Multiome | 1122 | |
| chr11:74,170,498–74,171,610 | 294.1 kb | Distal (>10kb) Multiome | 881 |
Genomic view of the PAAF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.