This nucleolar protein was first characterized because it was an autoantigen in cases on interstitial cystitis. The protein, with a predicted molecular weight of 50 kDa, appears to be localized in the particulate compartment of the interphase nucleolus, with a distribution distinct from that of nucleolar protein B23. During mitosis it is associated with chromosomes. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for P3H4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = P3H4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of P3H4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:41,527,111–41,529,407 | 284.2 kb | Distal (>10kb) Multiome | 635 | |
| chr17:41,529,883–41,531,145 | 282.1 kb | Distal (>10kb) Multiome | 504 | |
| chr17:41,548,740–41,549,518 | 263.5 kb | Distal (>10kb) Multiome | 698 | |
| chr17:41,579,549–41,580,064 | 232.9 kb | Distal (>10kb) Multiome | 335 | |
| chr17:41,647,765–41,648,495 | 164.6 kb | Distal (>10kb) Multiome | 519 | |
| chr17:41,662,549–41,663,015 | 149.8 kb | Distal (>10kb) Multiome | 643 | |
| chr17:41,665,564–41,667,291 | 145.4 kb | Distal (>10kb) Multiome | 883 | |
| chr17:41,688,103–41,690,064 | 123.8 kb | Distal (>10kb) Multiome | 1236 | |
| chr17:41,733,761–41,735,187 | 77.9 kb | Distal (>10kb) Multiome | 577 | |
| chr17:41,738,054–41,738,690 | 74.4 kb | Distal (>10kb) Multiome | 596 | |
| chr17:41,784,980–41,787,229 | 25.8 kb | Distal (>10kb) Multiome | 958 | |
| chr17:41,793,527–41,794,326 | 18.7 kb | Distal (>10kb) Multiome | 597 | |
| chr17:41,800,647–41,802,040 | 10.7 kb | Distal (>10kb) Multiome | 766 | |
| chr17:41,811,252–41,813,275 | 340 bp | At TSS Multiome | 997 | |
| chr17:41,835,756–41,836,400 | 23.6 kb | Distal (>10kb) Multiome | 568 | |
| chr17:41,864,608–41,865,695 | 52.8 kb | Distal (>10kb) Multiome | 913 | |
| chr17:41,913,670–41,914,569 | 101.5 kb | Distal (>10kb) Multiome | 190 | |
| chr17:41,918,026–41,919,794 | 106.6 kb | Distal (>10kb) Multiome | 956 | |
| chr17:41,930,220–41,930,908 | 117.9 kb | Distal (>10kb) Multiome | 915 | |
| chr17:41,965,771–41,967,327 | 154.2 kb | Distal (>10kb) Multiome | 920 | |
| chr17:42,016,953–42,018,102 | 204.9 kb | Distal (>10kb) Multiome | 991 | |
| chr17:42,019,726–42,020,334 | 207.4 kb | Distal (>10kb) Multiome | 791 | |
| chr17:42,050,326–42,051,046 | 238.0 kb | Distal (>10kb) Multiome | 514 | |
| chr17:42,107,497–42,108,335 | 295.3 kb | Distal (>10kb) Multiome | 357 |
Genomic view of the P3H4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.