The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for OXTR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OXTR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OXTR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:8,480,497–8,481,808 | 288.3 kb | Distal (>10kb) Multiome | 166 | |
| chr3:8,501,272–8,502,142 | 267.9 kb | Distal (>10kb) Multiome | 885 | |
| chr3:8,503,558–8,504,268 | 265.6 kb | Distal (>10kb) Multiome | 264 | |
| chr3:8,622,544–8,623,923 | 146.5 kb | Distal (>10kb) Multiome | 391 | |
| chr3:8,659,994–8,661,068 | 109.1 kb | Distal (>10kb) Multiome | 116 | |
| chr3:8,663,020–8,663,944 | 106.1 kb | Distal (>10kb) Multiome | 393 | |
| chr3:8,767,641–8,768,551 | 1.1 kb | Proximal (<10kb) | 241 | |
| chr3:8,768,956–8,769,996 | 120 bp | At TSS Multiome | 494 | |
| chr3:8,770,795–8,770,971 | 1.2 kb | Proximal (<10kb) | 7 | |
| chr3:8,882,072–8,882,855 | 112.8 kb | Distal (>10kb) Multiome | 91 | |
| chr3:8,962,788–8,963,860 | 193.8 kb | Distal (>10kb) Multiome HiCAR | 759 | |
| chr3:8,987,645–8,988,416 | 218.3 kb | Distal (>10kb) Multiome | 298 |
Genomic view of the OXTR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.