The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for OXSR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OXSR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OXSR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:37,986,618–37,987,603 | 178.4 kb | Distal (>10kb) Multiome | 525 | |
| chr3:37,993,686–37,994,594 | 171.3 kb | Distal (>10kb) Multiome | 519 | |
| chr3:37,998,336–37,999,630 | 166.4 kb | Distal (>10kb) Multiome | 510 | |
| chr3:38,003,084–38,004,028 | 162.0 kb | Distal (>10kb) Multiome | 352 | |
| chr3:38,023,878–38,025,927 | 140.7 kb | Distal (>10kb) Multiome | 762 | |
| chr3:38,028,710–38,030,184 | 135.9 kb | Distal (>10kb) Multiome | 378 | |
| chr3:38,039,093–38,039,944 | 126.2 kb | Distal (>10kb) Multiome | 357 | |
| chr3:38,136,419–38,139,307 | 26.8 kb | Distal (>10kb) Multiome | 989 | |
| chr3:38,164,619–38,166,160 | 267 bp | At TSS Multiome | 1040 | |
| chr3:38,345,594–38,347,388 | 181.3 kb | Distal (>10kb) Multiome HiCAR | 971 | |
| chr3:38,452,852–38,456,220 | 288.2 kb | Distal (>10kb) Multiome | 971 |
Genomic view of the OXSR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.