OXA1L

OXA1L mitochondrial inner membrane insertase | MGC133129, OXA1, OXA1L1

This gene encodes an evolutionarily conserved protein that is localized to the inner mitochondrial membrane. The encoded protein is essential for the translocation of the N-terminal tail of subunit 2 of cytochrome c oxidase, and is involved in the assembly of the cytochrome c oxidase and ATPase complexes of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2016]

Member of: DE-7

Biological processes 27 terms

aerobic respiration (GO:0009060)membrane (GO:0016020)membrane insertase activity (GO:0032977)membrane insertase activity (GO:0032977)membrane insertase activity (GO:0032977)membrane insertase activity (GO:0032977)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial matrix (GO:0005759)mitochondrial membrane (GO:0031966)mitochondrial protein quality control (GO:0141164)mitochondrial proton-transporting ATP synthase complex assembly (GO:0033615)mitochondrial respiratory chain complex I assembly (GO:0032981)mitochondrial ribosome binding (GO:0097177)mitochondrial translation (GO:0032543)mitochondrion (GO:0005739)mitochondrion (GO:0005739)negative regulation of ATP-dependent activity (GO:0032780)negative regulation of oxidoreductase activity (GO:0051354)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)protein insertion into mitochondrial inner membrane from matrix (GO:0032979)protein insertion into mitochondrial inner membrane from matrix (GO:0032979)protein tetramerization (GO:0051262)protein-containing complex (GO:0032991)

Expression (TPM)

TFs regulating OXA1L 0 TFs

Transcription factors with Perturb-seq knockdown data for OXA1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OXA1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to OXA1L

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OXA1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr14:22,556,665–22,557,670	209.5 kb	Distal (>10kb) Multiome HiCAR	771
chr14:22,560,678–22,561,385	205.7 kb	Distal (>10kb) Multiome HiCAR	502
chr14:22,570,258–22,571,116	196.2 kb	Distal (>10kb) Multiome	460
chr14:22,588,929–22,590,086	177.2 kb	Distal (>10kb) Multiome	964
chr14:22,597,878–22,599,136	168.4 kb	Distal (>10kb) Multiome	834
chr14:22,766,419–22,767,375	3 bp	At TSS Multiome	988
chr14:22,821,826–22,823,530	56.2 kb	Distal (>10kb) Multiome	649
chr14:22,829,704–22,830,328	63.2 kb	Distal (>10kb) Multiome	871
chr14:22,836,107–22,837,017	69.8 kb	Distal (>10kb) Multiome	320
chr14:22,852,845–22,853,709	86.6 kb	Distal (>10kb) Multiome	788
chr14:22,870,967–22,873,202	104.9 kb	Distal (>10kb) Multiome	1167
chr14:22,882,594–22,883,886	116.5 kb	Distal (>10kb) Multiome	289
chr14:22,886,371–22,887,824	120.5 kb	Distal (>10kb) Multiome	639
chr14:22,918,527–22,919,975	152.6 kb	Distal (>10kb) Multiome	641
chr14:22,928,961–22,930,849	162.8 kb	Distal (>10kb) Multiome	1108
chr14:22,956,530–22,957,512	190.4 kb	Distal (>10kb) Multiome	983
chr14:22,981,215–22,983,249	216.0 kb	Distal (>10kb) Multiome	935
chr14:23,006,674–23,007,583	240.5 kb	Distal (>10kb) Multiome	1097
chr14:23,020,642–23,021,291	254.3 kb	Distal (>10kb) Multiome	148

Genome Browser

Genomic view of the OXA1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.