Enables K48-linked deubiquitinase activity and cysteine-type deubiquitinase activity. Involved in several processes, including negative regulation of protein localization to nucleus; protein deubiquitination; and regulation of intracellular signal transduction. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for OTUD7B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OTUD7B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OTUD7B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:149,812,136–149,812,633 | 198.3 kb | Distal (>10kb) Multiome | 190 | |
| chr1:149,885,029–149,889,131 | 122.4 kb | Distal (>10kb) Multiome | 1126 | |
| chr1:149,899,425–149,900,227 | 111.0 kb | Distal (>10kb) Multiome | 650 | |
| chr1:149,927,507–149,928,019 | 82.8 kb | Distal (>10kb) Multiome | 744 | |
| chr1:150,010,143–150,011,088 | 33 bp | At TSS Multiome | 961 | |
| chr1:150,017,155–150,017,668 | 6.4 kb | Proximal (<10kb) | 118 | |
| chr1:150,066,903–150,067,886 | 57.0 kb | Distal (>10kb) Multiome | 986 | |
| chr1:150,149,493–150,150,439 | 139.4 kb | Distal (>10kb) Multiome | 448 | |
| chr1:150,162,838–150,163,636 | 152.6 kb | Distal (>10kb) Multiome | 550 | |
| chr1:150,213,532–150,214,095 | 203.1 kb | Distal (>10kb) Multiome | 441 | |
| chr1:150,234,435–150,235,519 | 224.1 kb | Distal (>10kb) Multiome | 725 | |
| chr1:150,235,635–150,236,696 | 225.6 kb | Distal (>10kb) Multiome | 905 | |
| chr1:150,255,443–150,256,199 | 245.1 kb | Distal (>10kb) Multiome | 441 | |
| chr1:150,256,563–150,257,324 | 246.4 kb | Distal (>10kb) Multiome | 223 | |
| chr1:150,257,589–150,258,594 | 247.5 kb | Distal (>10kb) Multiome | 233 | |
| chr1:150,259,728–150,260,778 | 249.4 kb | Distal (>10kb) Multiome | 362 | |
| chr1:150,268,574–150,269,453 | 258.4 kb | Distal (>10kb) Multiome | 785 | |
| chr1:150,281,629–150,283,038 | 271.8 kb | Distal (>10kb) Multiome | 503 | |
| chr1:150,293,680–150,294,144 | 283.2 kb | Distal (>10kb) Multiome | 755 |
Genomic view of the OTUD7B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.