Transcription factors with Perturb-seq knockdown data for OTUD6B-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OTUD6B-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OTUD6B-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:90,791,022–90,792,433 | 278.5 kb | Distal (>10kb) Multiome | 362 | |
| chr8:90,984,601–90,986,072 | 84.9 kb | Distal (>10kb) Multiome | 606 | |
| chr8:91,040,121–91,041,552 | 29.3 kb | Distal (>10kb) Multiome | 777 | |
| chr8:91,060,040–91,060,309 | 9.9 kb | Proximal (<10kb) | 19 | |
| chr8:91,069,419–91,071,048 | 31 bp | At TSS Multiome | 860 |
Genomic view of the OTUD6B-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.