Alternatively spliced transcript variants have been found for this gene. The smaller protein isoform encoded by the shorter transcript variant is found only in HIV-1 infected cells. [provided by RefSeq, Jul 2010]
Transcription factors with Perturb-seq knockdown data for OTUD4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OTUD4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OTUD4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:145,097,462–145,099,005 | 82.3 kb | Distal (>10kb) Multiome | 974 | |
| chr4:145,170,076–145,170,764 | 9.8 kb | Proximal (<10kb) | 20 | |
| chr4:145,177,574–145,177,774 | 2.8 kb | Proximal (<10kb) | 69 | |
| chr4:145,179,427–145,181,239 | 108 bp | At TSS Multiome | 855 | |
| chr4:145,618,861–145,619,971 | 438.8 kb | Distal (>10kb) Multiome HiCAR | 997 | |
| chr4:146,175,371–146,176,493 | 995.3 kb | Distal (>10kb) Multiome HiCAR | 738 |
Genomic view of the OTUD4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.