Enables cysteine-type deubiquitinase activity. Involved in cellular response to nutrient levels and protein deubiquitination. Acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; protein deubiquitination; and protein stabilization. Located in cytoplasm. Is active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for OTUD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OTUD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OTUD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:19,596,392–19,597,600 | 285.4 kb | Distal (>10kb) Multiome | 888 | |
| chr1:19,640,074–19,641,053 | 241.8 kb | Distal (>10kb) Multiome | 418 | |
| chr1:19,643,702–19,645,210 | 238.2 kb | Distal (>10kb) Multiome | 427 | |
| chr1:19,653,578–19,654,269 | 228.4 kb | Distal (>10kb) Multiome | 321 | |
| chr1:19,659,723–19,660,209 | 222.4 kb | Distal (>10kb) Multiome | 316 | |
| chr1:19,704,357–19,704,828 | 177.7 kb | Distal (>10kb) Multiome | 244 | |
| chr1:19,882,144–19,883,038 | 8 bp | At TSS Multiome | 815 | |
| chr1:19,957,927–19,958,660 | 75.8 kb | Distal (>10kb) Multiome | 53 | |
| chr1:20,152,028–20,152,628 | 270.1 kb | Distal (>10kb) Multiome | 449 |
Genomic view of the OTUD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.