The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for OTUB1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OTUB1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OTUB1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:63,761,764–63,765,204 | 222.3 kb | Distal (>10kb) Multiome | 463 | |
| chr11:63,767,471–63,769,982 | 218.8 kb | Distal (>10kb) Multiome | 627 | |
| chr11:63,813,022–63,814,238 | 173.0 kb | Distal (>10kb) Multiome | 704 | |
| chr11:63,838,214–63,839,799 | 147.5 kb | Distal (>10kb) Multiome | 687 | |
| chr11:63,888,171–63,888,861 | 97.9 kb | Distal (>10kb) Multiome | 565 | |
| chr11:63,909,610–63,910,221 | 76.5 kb | Distal (>10kb) Multiome | 113 | |
| chr11:63,916,069–63,921,372 | 66.9 kb | Distal (>10kb) Multiome | 929 | |
| chr11:63,938,087–63,939,846 | 47.6 kb | Distal (>10kb) Multiome | 852 | |
| chr11:63,974,156–63,975,123 | 11.9 kb | Distal (>10kb) Multiome | 918 | |
| chr11:63,986,198–63,987,213 | 103 bp | At TSS Multiome | 895 | |
| chr11:63,998,533–64,001,109 | 13.0 kb | Distal (>10kb) Multiome | 414 | |
| chr11:64,028,126–64,028,898 | 42.2 kb | Distal (>10kb) Multiome | 168 | |
| chr11:64,165,638–64,166,698 | 179.8 kb | Distal (>10kb) Multiome | 811 | |
| chr11:64,184,927–64,186,817 | 199.5 kb | Distal (>10kb) Multiome | 1091 | |
| chr11:64,225,548–64,226,862 | 239.8 kb | Distal (>10kb) Multiome | 776 | |
| chr11:64,230,074–64,231,130 | 244.1 kb | Distal (>10kb) Multiome | 715 | |
| chr11:64,233,950–64,235,296 | 248.0 kb | Distal (>10kb) Multiome | 590 | |
| chr11:64,240,398–64,242,687 | 254.8 kb | Distal (>10kb) Multiome | 982 | |
| chr11:64,246,274–64,248,065 | 260.7 kb | Distal (>10kb) Multiome | 802 | |
| chr11:64,250,699–64,251,842 | 265.0 kb | Distal (>10kb) Multiome | 498 | |
| chr11:64,268,509–64,270,920 | 283.7 kb | Distal (>10kb) Multiome | 1093 | |
| chr11:64,271,352–64,271,994 | 285.2 kb | Distal (>10kb) Multiome | 595 | |
| chr11:64,284,095–64,286,666 | 299.3 kb | Distal (>10kb) Multiome | 807 |
Genomic view of the OTUB1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.