Predicted to enable growth factor activity. Predicted to be involved in negative regulation of cell growth. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for OSGIN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OSGIN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OSGIN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:89,735,590–89,737,765 | 166.5 kb | Distal (>10kb) Multiome | 299 | |
| chr8:89,757,049–89,758,721 | 144.9 kb | Distal (>10kb) Multiome | 975 | |
| chr8:89,900,838–89,901,579 | 989 bp | At TSS | 221 | |
| chr8:89,901,706–89,903,339 | 118 bp | At TSS Multiome | 906 | |
| chr8:89,983,654–89,985,025 | 81.8 kb | Distal (>10kb) Multiome HiCAR | 1128 | |
| chr8:89,992,539–89,993,861 | 90.4 kb | Distal (>10kb) Multiome | 132 | |
| chr8:90,000,653–90,002,462 | 98.7 kb | Distal (>10kb) Multiome | 917 | |
| chr8:90,081,366–90,083,237 | 180.2 kb | Distal (>10kb) Multiome | 562 | |
| chr8:91,040,121–91,041,552 | 1138.3 kb | Distal (>10kb) Multiome HiCAR | 777 |
Genomic view of the OSGIN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.