This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This family member functions as a cholesterol transfer protein that regulates Golgi structure and function. Multiple transcript variants, most of which encode distinct isoforms, have been identified. Related pseudogenes have been identified on chromosomes 3, 11 and 12. [provided by RefSeq, Jul 2010]
Transcription factors with Perturb-seq knockdown data for OSBPL9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OSBPL9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OSBPL9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:51,330,127–51,331,039 | 286.5 kb | Distal (>10kb) Multiome | 288 | |
| chr1:51,344,517–51,345,671 | 272.1 kb | Distal (>10kb) Multiome | 345 | |
| chr1:51,517,972–51,519,630 | 99.0 kb | Distal (>10kb) Multiome | 979 | |
| chr1:51,616,886–51,617,753 | 52 bp | At TSS Multiome | 626 | |
| chr1:51,729,098–51,730,258 | 112.6 kb | Distal (>10kb) Multiome | 828 | |
| chr1:51,877,934–51,879,493 | 261.8 kb | Distal (>10kb) Multiome | 1012 | |
| chr1:51,957,425–51,958,172 | 340.7 kb | Distal (>10kb) Multiome | 194 | |
| chr1:51,960,124–51,960,875 | 343.4 kb | Distal (>10kb) Multiome | 141 | |
| chr1:51,989,938–51,991,038 | 373.6 kb | Distal (>10kb) Multiome | 410 |
Genomic view of the OSBPL9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.