Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for OSBP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OSBP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OSBP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:59,549,065–59,551,594 | 65.2 kb | Distal (>10kb) Multiome | 1090 | |
| chr11:59,555,666–59,556,747 | 59.5 kb | Distal (>10kb) Multiome | 594 | |
| chr11:59,556,871–59,557,924 | 58.2 kb | Distal (>10kb) Multiome | 658 | |
| chr11:59,559,914–59,561,504 | 55.1 kb | Distal (>10kb) Multiome | 784 | |
| chr11:59,565,720–59,566,773 | 49.5 kb | Distal (>10kb) Multiome | 857 | |
| chr11:59,615,036–59,616,897 | 270 bp | At TSS Multiome | 851 | |
| chr11:59,667,993–59,670,036 | 53.4 kb | Distal (>10kb) Multiome | 868 | |
| chr11:59,681,135–59,682,105 | 65.8 kb | Distal (>10kb) Multiome | 234 | |
| chr11:59,753,782–59,756,695 | 139.6 kb | Distal (>10kb) Multiome | 945 | |
| chr11:59,801,909–59,802,832 | 186.5 kb | Distal (>10kb) Multiome HiCAR | 305 | |
| chr11:59,809,850–59,811,292 | 195.0 kb | Distal (>10kb) Multiome | 960 |
Genomic view of the OSBP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.