The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for ORAI1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ORAI1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ORAI1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:121,351,979–121,352,906 | 274.0 kb | Distal (>10kb) Multiome | 928 | |
| chr12:121,399,561–121,400,983 | 226.5 kb | Distal (>10kb) Multiome | 923 | |
| chr12:121,443,293–121,443,776 | 183.0 kb | Distal (>10kb) Multiome | 302 | |
| chr12:121,466,702–121,468,225 | 159.1 kb | Distal (>10kb) Multiome | 643 | |
| chr12:121,536,039–121,536,480 | 90.2 kb | Distal (>10kb) Multiome | 262 | |
| chr12:121,576,794–121,577,632 | 49.4 kb | Distal (>10kb) Multiome | 171 | |
| chr12:121,580,160–121,581,909 | 46.1 kb | Distal (>10kb) Multiome HiCAR | 629 | |
| chr12:121,582,525–121,583,038 | 43.7 kb | Distal (>10kb) Multiome HiCAR | 309 | |
| chr12:121,624,692–121,625,049 | 1.5 kb | Proximal (<10kb) | 323 | |
| chr12:121,625,878–121,627,559 | 8 bp | At TSS Multiome | 904 | |
| chr12:121,632,871–121,633,543 | 6.4 kb | Proximal (<10kb) | 335 | |
| chr12:121,671,731–121,673,334 | 46.0 kb | Distal (>10kb) Multiome | 548 | |
| chr12:121,686,676–121,687,782 | 60.6 kb | Distal (>10kb) Multiome | 907 | |
| chr12:121,712,130–121,713,412 | 86.3 kb | Distal (>10kb) Multiome | 731 | |
| chr12:121,792,642–121,795,650 | 167.6 kb | Distal (>10kb) Multiome | 1009 | |
| chr12:121,797,071–121,801,369 | 172.1 kb | Distal (>10kb) Multiome | 1126 | |
| chr12:121,802,658–121,804,393 | 176.6 kb | Distal (>10kb) Multiome | 825 | |
| chr12:121,812,380–121,813,114 | 185.9 kb | Distal (>10kb) Multiome | 458 | |
| chr12:121,839,137–121,840,260 | 213.1 kb | Distal (>10kb) Multiome | 564 | |
| chr12:121,888,344–121,889,335 | 262.3 kb | Distal (>10kb) Multiome | 1141 | |
| chr12:121,918,184–121,919,001 | 292.1 kb | Distal (>10kb) Multiome | 407 |
Genomic view of the ORAI1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.