This gene encodes an olfactomedin domain-containing protein. Most olfactomedin domain-containing proteins are secreted glycoproteins. [provided by RefSeq, Dec 2016]
Transcription factors with Perturb-seq knockdown data for OLFML2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OLFML2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OLFML2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:161,725,801–161,727,799 | 296.7 kb | Distal (>10kb) Multiome | 770 | |
| chr1:161,749,531–161,750,743 | 274.0 kb | Distal (>10kb) Multiome | 1002 | |
| chr1:162,023,209–162,024,534 | 11 bp | At TSS Multiome | 452 | |
| chr1:162,069,229–162,071,225 | 45.9 kb | Distal (>10kb) Multiome | 662 | |
| chr1:162,144,614–162,146,203 | 121.4 kb | Distal (>10kb) Multiome | 523 |
Genomic view of the OLFML2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.