Involved in positive regulation of smooth muscle cell differentiation. Acts upstream of or within protein secretion. Located in cytoplasm; extracellular region; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for OLFM2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OLFM2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OLFM2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:9,674,791–9,675,456 | 261.2 kb | Distal (>10kb) Multiome | 793 | |
| chr19:9,768,230–9,769,267 | 167.6 kb | Distal (>10kb) Multiome | 893 | |
| chr19:9,784,209–9,786,632 | 150.5 kb | Distal (>10kb) Multiome | 727 | |
| chr19:9,791,515–9,793,483 | 143.6 kb | Distal (>10kb) Multiome | 507 | |
| chr19:9,818,302–9,820,113 | 117.0 kb | Distal (>10kb) Multiome | 870 | |
| chr19:9,827,304–9,828,194 | 108.5 kb | Distal (>10kb) Multiome | 742 | |
| chr19:9,834,598–9,835,806 | 101.2 kb | Distal (>10kb) Multiome | 681 | |
| chr19:9,913,549–9,914,444 | 22.6 kb | Distal (>10kb) Multiome | 322 | |
| chr19:9,914,501–9,914,999 | 21.5 kb | Distal (>10kb) Multiome | 587 | |
| chr19:9,930,954–9,931,148 | 5.2 kb | Proximal (<10kb) | 199 | |
| chr19:9,933,993–9,934,841 | 2.0 kb | Proximal (<10kb) Multiome | 425 | |
| chr19:9,935,627–9,937,234 | 145 bp | At TSS Multiome | 297 | |
| chr19:10,027,570–10,028,022 | 91.5 kb | Distal (>10kb) Multiome HiCAR | 753 | |
| chr19:10,086,000–10,086,942 | 150.0 kb | Distal (>10kb) Multiome | 614 | |
| chr19:10,095,848–10,096,951 | 159.9 kb | Distal (>10kb) Multiome | 572 | |
| chr19:10,106,123–10,106,748 | 170.0 kb | Distal (>10kb) Multiome | 842 | |
| chr19:10,113,011–10,113,478 | 176.9 kb | Distal (>10kb) Multiome | 511 | |
| chr19:10,119,464–10,120,287 | 183.6 kb | Distal (>10kb) Multiome HiCAR | 818 | |
| chr19:10,194,229–10,195,372 | 258.6 kb | Distal (>10kb) Multiome | 939 | |
| chr19:10,230,671–10,231,665 | 295.1 kb | Distal (>10kb) Multiome | 595 |
Genomic view of the OLFM2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.