This gene product shares extensive sequence similarity with the rat neuronal olfactomedin-related ER localized protein. While the exact function of the encoded protein is not known, its abundant expression in brain suggests that it may have an essential role in nerve tissue. Several alternatively spliced transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for OLFM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OLFM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OLFM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:135,075,146–135,075,746 | 2 bp | At TSS Multiome | 207 | |
| chr9:135,086,093–135,086,347 | 1.3 kb | Proximal (<10kb) | 484 | |
| chr9:135,087,089–135,088,354 | 12.2 kb | Distal (>10kb) Multiome | 270 | |
| chr9:135,136,832–135,137,959 | 62.1 kb | Distal (>10kb) Multiome | 277 | |
| chr9:135,468,994–135,469,760 | 393.9 kb | Distal (>10kb) Multiome HiCAR | 289 | |
| chr9:135,478,873–135,480,868 | 404.2 kb | Distal (>10kb) Multiome HiCAR | 587 |
Genomic view of the OLFM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.