The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for OGFR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = OGFR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of OGFR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:62,641,913–62,643,114 | 162.5 kb | Distal (>10kb) Multiome | 874 | |
| chr20:62,791,452–62,791,941 | 13.2 kb | Distal (>10kb) Multiome | 645 | |
| chr20:62,793,003–62,795,717 | 10.5 kb | Distal (>10kb) Multiome | 1051 | |
| chr20:62,795,820–62,796,113 | 8.7 kb | Proximal (<10kb) | 334 | |
| chr20:62,796,248–62,797,075 | 8.3 kb | Proximal (<10kb) Multiome | 566 | |
| chr20:62,804,667–62,805,076 | at TSS | At TSS | 512 | |
| chr20:62,808,356–62,808,554 | 3.5 kb | Proximal (<10kb) | 312 | |
| chr20:62,815,479–62,817,462 | 12.2 kb | Distal (>10kb) Multiome | 503 | |
| chr20:62,824,643–62,825,353 | 20.3 kb | Distal (>10kb) Multiome | 339 | |
| chr20:62,860,497–62,862,892 | 57.1 kb | Distal (>10kb) Multiome | 996 | |
| chr20:62,900,083–62,900,558 | 95.6 kb | Distal (>10kb) Multiome | 764 | |
| chr20:62,925,950–62,926,856 | 121.7 kb | Distal (>10kb) Multiome | 874 | |
| chr20:62,928,980–62,929,573 | 124.5 kb | Distal (>10kb) Multiome | 289 | |
| chr20:62,937,285–62,938,569 | 133.2 kb | Distal (>10kb) Multiome | 1026 | |
| chr20:63,006,367–63,007,246 | 202.1 kb | Distal (>10kb) Multiome | 189 | |
| chr20:63,071,594–63,072,696 | 267.1 kb | Distal (>10kb) Multiome | 246 |
Genomic view of the OGFR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.